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Learning Curve in ALPPS

Jun Li
Department / Institution: 
University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Date Project Approved: 
Sunday, 18 May, 2014
Project Status: 
Application / Abstract: 
Since ALPPS was introduced into the liver surgery, more than 300 procedures have been performed. The technical aspects and pitfalls of the procedure were recently reported by the many groups worldwide. Along with its impressive efficacy for a rapid liver hypertrophy which made many marginally resectable or non-resectable liver malignancy resectable and sufficient volume increase after unsuccessful portal vein occlusion, high rate of severe complication (40%) and mortality (12%) from the initial report has been the mainly concern. Recently, the international ALPPS registry, which was initiated in 2012, reported the results of 202 cases from 41 centers between 10/2012 and 12/2013, having 26% severe complication rate and 9% 90-day mortality rate. If less than 8 cases per center considered as low volume center, the registry data probably did not reflect the real safety of this procedure because the majority cases reported (155 from 202, 77%) were still among the learning curve.
To reveal the true safety of ALPPS, we would like to analyze the registry data regarding the learning curve.
The patient selection, operation time, postoperative complication would be studied according to case loading per center (low volume and high volume center) and time period (2010-2012, 2013-2014).


University Hospital Zurich
Department of Surgery
Raemistrasse 100
8091 Zurich, Switzerland


Phone: +41 (0)44 255 33 00
Fax:     +41 (0)44 255 44 49