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Impact of ALPPS on colorectal tumor growth

P. Kambakamba and M. Lesurtel
Department / Institution: 
University Hospital Zurich, Switzerland
Date Project Approved: 
Friday, 20 November, 2015
Project Status: 
ALPPS induces an unprecedented liver hypertrophy and enables resection of primarily unresectable liver tumors. However the effect of ALPPS on tumor proliferation remains a concern. Indeed micrometastases in the FLR might likewise be affected by the proliferative stimulus induced by ALPPS. Observations in a mouse model do not indicate increased intra hepatic or pulmonary tumor growth after ALPPS as compared with portal vein ligation (PVL) or sham controls. In human, knowledge about tumor growth after ALPPS stage 1 in the FLR is lacking, as this is a rare scenario and cleaning of the FLR is routinely performed.
The aim of this study is to investigate the impact of ALPPS on tumor growth of colorectal liver metastases in the future liver remnant (FLR) in mice and human.
Using the International ALPPS registry, we plan to identify patients with remaining tumor in the FLR after stage 1. Using volumetric data, tumor growth kinetics prior to stage 1 will be compared with tumor growth kinetics after stage 1. These findings will be reported in a translational manner together with observations from an ALPPS mouse model.


University Hospital Zurich
Department of Surgery
Raemistrasse 100
8091 Zurich, Switzerland


Phone: +41 (0)44 255 33 00
Fax:     +41 (0)44 255 44 49