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Validation of the ALPPS Risk Score

Michael Linecker & Henrik Petrowsky
Department / Institution: 
University Hospital Zurich, Switzerland
Date Project Approved: 
Monday, 28 November, 2016
Project Status: 
Application / Abstract: 
ALPPS is in strong need of precise risk stratification. To address this important issue, an easy applicable Risk Score predicting 90d or in-hospital mortality pre-stage 1 and 2 has been proposed using the International ALPPS Registry (Linecker M, Petrowsky H, Ann Surg. 2016). Due to the nature of the registry data capturing the majority of the international ALPPS experience at the time of score development a validation has not been performed yet.
The aim of this study is to internally and externally validate the recently proposed ALPPS Risk Score one year after development.
The international ALPPS registry will be screened for cases entered after development of the ALPPS Risk Score applying the same in- and exclusion criteria (internal validation). In addition, high- volume ALPPS centers outside the International ALPPS registry will be contacted to provide cases (external validation). In all patients with available 90d follow-up pre-stage 1 and 2 futility risks will be calculated and compared with the actual survival outcome. ROC curve analysis will performed to assess the predictive ability of the ALPPS Risk Score in the validation cohort.


University Hospital Zurich
Department of Surgery
Raemistrasse 100
8091 Zurich, Switzerland


Phone: +41 (0)44 255 33 00
Fax:     +41 (0)44 255 44 49