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A critical appraisal of liver growth reporting in ALPPS

published by Michael Linecker on 29 March, 2016 - 13:03
Applicants: 
Michael Linecker and Henrik Petrowsky
Department / Institution: 
Swiss HPB and Transplant Center, University Hospital Zurich, Zurich, Zurich, Switzerland
Date Project Submitted: 
Monday, 15 February, 2016
Date Project Approved: 
Friday, 11 March, 2016
Project Status: 
Approved
Application / Abstract: 
PDF icon ALPPS liver growth reporting.pdf
Background: 
Following the first reports of exceptional liver growth in ALPPS, a large variety of measures quantifying liver growth have been developed. The abundance of these growth measures, however, makes a comparison between centers difficult. Experiences from our ALPPS cohort hint at a particularly high variance of liver growth reporting per time. In contrast to common assumptions, liver growth after stage 1 indicates a non-linear time pattern. Definitive time points of volumetry before stage 2 are therefore key making kinetic growth rates comparable.
Objectives: 
The aim of this study is to critically evaluate and improve liver growth reporting in ALPPS. Overall Goal: To give recommendations how to report appropriately growth kinetic in ALPPS in order to provide comparability of results on hypertrophy among different studies.
Methods: 
Liver growth characteristics will be divided in two broad categories: Static and Dynamic liver growth parameters. Static liver growth parameters reflect absolute or relative liver volumes at stage 1 and 2 as well as their change. Dynamic liver growth parameters, also known as kinetic growth curve, include volume changes calculated per day or per week. The analysis will be performed in 2 steps: 1.) Identifying static and dynamic liver growth parameters of ALPPS in the literature 2.) Creating a liver growth curve depending on the time of volumetry after stage 1 using the International ALPPS Registry.

Headquarters

University Hospital Zurich
Department of Surgery
Raemistrasse 100
8091 Zurich, Switzerland

Contacts

Phone: +41 (0)44 255 33 00
Fax:     +41 (0)44 255 44 49
Email:  ALPPS@usz.ch